*** The key C-x m no longer runs the `mail' command directly.
Instead, it runs the command `compose-mail', which invokes the mail composition mechanism you have selected with the variable `mail-user-agent'. The default choice of user agent is `sendmail-user-agent', which gives behavior compatible with the old behavior.

C-x 4 m now runs compose-mail-other-window, and C-x 5 m runs compose-mail-other-frame.